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雙咪唑

基本信息

[英文名稱]
2-N-PROPYL-4-METHYL-6-(1'-METHYLBENZIMIDAZOL-2-YL)BENZIMIDAZOLE

[英文別名]
2-n-Propyl-4-methyl-6-(1'-methylbenzimidazole-2-yl)benzimidazole; Bis-Benzoimidazole 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl) _benzimidazole; 2-n-propyl-4-methyl-6-(1-methyl benzimidazole-2-yl)benzimidazole; 2-n-Propyl-4-Methyl-6-(1-Methyl Benzimidazole-2-yl)-Benzimidazole; 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole; 2-n-Propyl-4-methyl-6-(1'-methylbenzimidazole-2-yl)benzimidazol; 2-n-propyl-4-methyl-6-(methylbenzimidazol-2-yl) benzimidazole; Double benzimidazole; 1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole; 1,7'-Dimethyl-2'-propyl-2,5'-bi-1H-benzimidazole; 2-N-Propyl-4-Methyl-6-(1-Methyl Benzimidazole-2-yl) Benzimidazole; 1H-BENZIMIDAZOL-2-N-PROPYL-4-METHYL-6-(1-METHYL BENZIMIDAZOL)-2-YL

[CAS號]
152628-02-9

[分子式]
C19H20N4

[分子量]
304.3889

說明書

中文全稱：2-正丙基-4-甲基-6-(1'-甲基苯并咪唑-2-基)苯并咪唑，英文全稱：2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole，CAS No. 152628-02-9，合成降壓藥替米沙坦（CAS No. 144701-48-4）的關(guān)鍵中間體。

作用

由單咪唑酸（7-甲基-2-丙基-3H-苯并咪唑-5-羧酸，CAS No.152628-03-0）與在多聚磷酸作用下與N-甲基鄰苯二胺鹽酸鹽（CAS No.25148-68-9）環(huán)合制備。雙咪唑與4’ -溴甲基-聯(lián)苯基-2-羧酸酯進(jìn)行親核取代反應(yīng)制備替米沙坦。

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