動(dòng)態(tài)軸向壓縮系統(tǒng)
動(dòng)態(tài)軸向壓縮系統(tǒng)是為工業(yè)化高壓制備色譜而研發(fā)的可自動(dòng)填裝色譜柱。主要應(yīng)用領(lǐng)域有：（1）高附加值產(chǎn)品（如紫杉醇等）提純（2）上樣量大，附加值低產(chǎn)品（甜菊糖苷等附加值低的藥物輔料）生產(chǎn)（3）工藝改進(jìn)類產(chǎn)品（增大產(chǎn)量或提高產(chǎn)品純度類產(chǎn)品）
其優(yōu)點(diǎn)在于：
1）裝柱時(shí)間短，無(wú)需二次拆裝，所以可避免傳統(tǒng)色譜柱在拆裝時(shí)柱床反彈影響柱效。
2）活塞頭與柱床始終接觸并保持裝柱壓力，避免了傳統(tǒng)色譜柱長(zhǎng)時(shí)間使用后柱床塌陷的問(wèn)題，延長(zhǎng)使用壽命。
3）不使用電氣零部件，可用于防爆區(qū)域（或者可采用使用防爆電機(jī)的液壓站）。
我公司生產(chǎn)的動(dòng)態(tài)軸向壓縮色譜柱（DAC）相比其它廠家產(chǎn)品的優(yōu)勢(shì)在于：
1）采用液壓站替代氣動(dòng)液壓放大泵。其優(yōu)勢(shì)在于液壓站輸出壓力平緩，液壓缸勻速下降，避免了氣動(dòng)液壓放大泵間歇輸出帶來(lái)的沖擊力，既保護(hù)了填料又避免了設(shè)備整體對(duì)地面的沖擊。
2）管路布局更為簡(jiǎn)潔。只有連接液壓缸的兩根油guan，其它管路都高度集成，整體性更好。拆裝色譜柱時(shí)空間更大更方便。
3）可以使用氣動(dòng)及電動(dòng)兩種動(dòng)力來(lái)源。在某些特定場(chǎng)合壓縮空氣輸出壓力及產(chǎn)生的壓縮空氣量并不能滿足氣動(dòng)液壓放大泵的使用，造成裝柱壓力不夠、裝柱時(shí)間長(zhǎng)而影響柱效。同時(shí)有的實(shí)驗(yàn)室并不具備壓縮空氣，無(wú)論采用氣瓶或者空氣壓縮機(jī)都會(huì)產(chǎn)生額外的費(fèi)用及噪音。而采用電動(dòng)驅(qū)動(dòng)采用的防爆電機(jī)可以與泵及檢測(cè)器使用相同的電源。
4）在直徑超過(guò)800mm的DAC上，氣動(dòng)液壓放大泵由于流量及壓力的限制會(huì)使裝柱時(shí)間明顯延長(zhǎng)。采用液壓站則可以使用流速大壓力低的泵來(lái)實(shí)現(xiàn)快速裝柱，同時(shí)配合一個(gè)小的氣動(dòng)液壓放大泵在裝柱完成后用于保壓。
200mmDAC技術(shù)參數(shù)
|
柱管 |
內(nèi)徑 |
200mm |
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長(zhǎng)度 |
650mm（可定制） |
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|
內(nèi)壁加工工藝 |
珩磨，拋光 |
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內(nèi)壁表面粗糙度 |
Ra≤0.4um |
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|
柱床高度 |
300mm |
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|
耐壓 |
100bar |
|
|
濾板 |
孔徑 |
5um |
|
材質(zhì) |
316L編織金屬濾板 |
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|
密封圈 |
材質(zhì) |
PTFE |
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結(jié)構(gòu) |
彈簧預(yù)緊V型密封圈 |
|
|
動(dòng)力單元 （2選1） |
液壓站（氣動(dòng)） |
空氣消耗量MAX1200NL/min |
|
液壓站（電動(dòng)） |
電源交流380V，3Kw |
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控制單元 |
安全閥 |
具有超壓保護(hù)功能 |
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切換閥 |
切換液壓缸方向（上、下、Hold） |
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壓力調(diào)節(jié)閥 |
調(diào)節(jié)泵輸出壓力 |
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壓力表 |
工作時(shí)氣壓、油壓 |
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急停按鈕 |
急停 |
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|
連接 |
進(jìn)口/出口 |
OD6mm管路，M14×1.5螺紋 |
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空氣 |
10mm氣管快插接頭 |
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|
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安裝運(yùn)行要求 |
工作溫度及濕度 |
10~40℃，≤50%RH |
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外形尺寸 |
請(qǐng)咨詢 |
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重量 |
請(qǐng)咨詢 |
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運(yùn)行條件 |
8bar壓縮空氣 |
|
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油箱容積 |
18L |
|
|
油壓與柱床壓比例 |
1.8:1 |
所有與液體接觸材質(zhì)包括：316L，PTFE，PEEK
Dynamic axial compression system
The Dynamic Axial Compression System is an auto-packed column developed for industrial, high-pressure preparative chromatography. The main application fields are: (1) purification of high value-added products (such as paclitaxel, etc.) (2) production of large sample load and low value-added products (steviol glycosides and other low value-added pharmaceutical excipients) (3) process improvement products (products that increase output or improve product purity)
The advantages are:
1) The column loading time is short, and there is no need for secondary disassembly, so it can avoid the rebound of the column bed during the disassembly and assembly of the traditional chromatographic column, which can affect the column efficiency.
2) The piston head is always in contact with the column bed and maintains the column loading pressure, which avoids the problem of column bed collapse after long-term use of the traditional chromatographic column and prolongs the service life.
3) No electrical parts are used, and can be used in explosion-proof areas (or hydraulic stations using explosion-proof motors can be used).
The advantages of our company's dynamic axial compression column (DAC) compared with other manufacturers' products are:
1) Adopt hydraulic station instead of pneumatic hydraulic amplification pump. Its advantage is that the output pressure of the hydraulic station is gentle, and the hydraulic cylinder decreases at a constant speed, which avoids the impact force brought by the intermittent output of the pneumatic hydraulic amplification pump, which not only protects the packing but also avoids the impact of the equipment on the ground as a whole.
2) The pipeline layout is more concise. Only the two oil pipes connected to the hydraulic cylinder, the other pipelines are highly integrated, and the integrity is better. More space and convenience when disassembling and assembling the column.
3) Pneumatic and electric power sources can be used. In some specific occasions, the output pressure of compressed air and the amount of compressed air generated cannot meet the use of pneumatic hydraulic amplification pump, resulting in insufficient column loading pressure and long column loading time and affecting column efficiency. At the same time, some laboratories do not have compressed air, and the use of gas cylinders or air compressors will generate additional costs and noise. Explosion-proof motors with electric drives can use the same power supply as pumps and detectors.
4) On DACs with a diameter of more than 800mm, the pneumatic hydraulic amplification pump will significantly extend the column loading time due to the limitation of flow and pressure. With the hydraulic station, a pump with a high flow rate and low pressure can be used to achieve rapid column loading, and a small pneumatic hydraulic amplification pump can be used to maintain pressure after the column loading is completed.
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